• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Defined dimensional changes in enzyme substrates and cofactors. Synthesis of lin-benzoadenosine and enzymatic evaluation of derivatives of the benzopurines.

作者信息

Leonard N J, Sprecker M A, Morrice A G

出版信息

J Am Chem Soc. 1976 Jun 23;98(13):3987-94. doi: 10.1021/ja00429a040.

DOI:10.1021/ja00429a040
PMID:819479
Abstract
摘要

相似文献

1
Defined dimensional changes in enzyme substrates and cofactors. Synthesis of lin-benzoadenosine and enzymatic evaluation of derivatives of the benzopurines.酶底物和辅因子中确定的尺寸变化。线性苯并腺苷的合成及苯并嘌呤衍生物的酶促评估。
J Am Chem Soc. 1976 Jun 23;98(13):3987-94. doi: 10.1021/ja00429a040.
2
Defined dimensional changes in enzyme cofactors: fluorescent "stretched-out" analogs of adenine nucleotides.
Science. 1977 Jan 21;195(4275):296-8. doi: 10.1126/science.188137.
3
A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase.
Eur J Biochem. 1990 Feb 22;188(1):155-63. doi: 10.1111/j.1432-1033.1990.tb15383.x.
4
Synthesis and biochemical evaluation of 2'-deoxy-lin-benzoadenosine phosphates.2'-脱氧连苯甲酰腺苷磷酸酯的合成与生化评价
Biochemistry. 1984 Aug 14;23(17):3868-73. doi: 10.1021/bi00312a012.
5
5'-Methylthioadenosine phosphorylase-L. Substrate activity of 5'-deoxyadenosine with the enzyme from Sarcoma 180 cells.5'-甲硫基腺苷磷酸化酶-L。5'-脱氧腺苷与肉瘤180细胞来源的该酶的底物活性。
Biochem Pharmacol. 1981 Feb 1;30(3):189-99. doi: 10.1016/0006-2952(81)90077-0.
6
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.8-氮杂免疫核苷作为嘌呤核苷磷酸化酶和核苷水解酶的过渡态类似物抑制剂。
J Med Chem. 2003 Jan 2;46(1):155-60. doi: 10.1021/jm0203332.
7
Synthesis of a potent transition-state inhibitor of 5'-deoxy-5'-methylthioadenosine phosphorylase.
J Med Chem. 2004 Mar 11;47(6):1322-4. doi: 10.1021/jm030455+.
8
Effect of lin-benzoadenosine and lin-benzoadenosine 3':5'-monophosphate on cyclic AMP-dependent protein kinase activity in vitro.林-苯甲腺苷和3':5'-环磷腺苷-林-苯甲腺苷对体外环磷酸腺苷依赖性蛋白激酶活性的影响。
J Cyclic Nucleotide Res. 1978 Jun;4(3):201-7.
9
Trypanosoma cruzi adenine nucleoside phosphorylase. Purification and substrate specificity.克氏锥虫腺嘌呤核苷磷酸化酶。纯化及底物特异性
Biochem Pharmacol. 1987 Feb 15;36(4):553-60. doi: 10.1016/0006-2952(87)90366-2.
10
Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase.与腺苷脱氨酶和嘌呤核苷磷酸化酶基因缺陷相关的不同免疫缺陷状态的可能代谢基础。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3848-52. doi: 10.1073/pnas.79.12.3848.

引用本文的文献

1
Novel tricycle expanded purine nucleosides with pan-viral activity.具有泛病毒活性的新型三轮扩展嘌呤核苷。
Bioorg Med Chem. 2025 Dec 1;130:118384. doi: 10.1016/j.bmc.2025.118384. Epub 2025 Sep 8.
2
Unnatural bases for recognition of noncoding nucleic acid interfaces.识别非编码核酸界面的非天然碱基。
Biopolymers. 2021 Jan;112(1):e23399. doi: 10.1002/bip.23399. Epub 2020 Sep 24.
3
The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold.
抗病毒核苷类似物的进化：化学家和非化学家的综述。第二部分：核苷骨架的复杂修饰。
Antiviral Res. 2019 Feb;162:5-21. doi: 10.1016/j.antiviral.2018.11.016. Epub 2018 Dec 8.
4
The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold.核苷类似物抗病毒药物的演进：化学家与非化学家的综述。第 1 部分：核苷骨架的早期结构修饰。
Antiviral Res. 2018 Jun;154:66-86. doi: 10.1016/j.antiviral.2018.04.004. Epub 2018 Apr 10.
5
Flexibility-Not just for yoga anymore!灵活性——不再只是瑜伽的专属！
Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618756788. doi: 10.1177/2040206618756788.
6
Fluorescent nucleobases as tools for studying DNA and RNA.荧光碱基作为研究 DNA 和 RNA 的工具。
Nat Chem. 2017 Nov;9(11):1043-1055. doi: 10.1038/nchem.2859. Epub 2017 Oct 16.
7
Thiophene-expanded guanosine analogues of Gemcitabine.吉西他滨的噻吩扩展鸟苷类似物。
Bioorg Med Chem Lett. 2015 Oct 1;25(19):4274-6. doi: 10.1016/j.bmcl.2015.07.086. Epub 2015 Jul 30.
8
lin-Benzo-ATP and-ADP: Versatile fluorescent probes for spectroscopic and biochemical studies.林-Benzo-ATP 和 ADP：用于光谱和生化研究的多功能荧光探针。
J Fluoresc. 1994 Sep;4(3):247-50. doi: 10.1007/BF01878458.
9
Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases.用尺寸扩大的 RNA 碱基鉴定 RNA 干扰中的 RISC 的空间位阻。
ACS Chem Biol. 2012 Aug 17;7(8):1454-61. doi: 10.1021/cb300174c. Epub 2012 Jun 12.
10
Fluorescent DNA-based enzyme sensors.荧光 DNA 酶传感器。
Chem Soc Rev. 2011 Dec;40(12):5756-70. doi: 10.1039/c0cs00162g. Epub 2011 Feb 2.