Hara R, Nakai E, Hisamichi H, Nagano N
Infectious Disease and Immunology Research Laboratories, Yamanouchi Pharmaceutical Co., LTD., Ibaraki, Japan.
J Antibiot (Tokyo). 1994 Apr;47(4):477-86. doi: 10.7164/antibiotics.47.477.
An improved synthesis and in vitro activity of cephalosporins with a (4-carboxy-3-hydroxy-5-isothiazolyl)thiomethyl group at the 3-position and its application to the preparation of new derivatives are described. These compounds showed excellent activity against Gram-negative bacteria including beta-lactamase producing strains. Among them, 2f was the most interesting because of its broad spectrum of antibacterial activity, including Gram-positive bacteria, and its outstanding inhibitory potency against Pseudomonas aeruginosa.
描述了3位带有（4-羧基-3-羟基-5-异噻唑基）硫甲基的头孢菌素的改进合成方法、体外活性及其在制备新衍生物中的应用。这些化合物对包括产β-内酰胺酶菌株在内的革兰氏阴性菌显示出优异的活性。其中，2f最为引人关注，因为它具有广谱抗菌活性，包括对革兰氏阳性菌，并且对铜绿假单胞菌具有出色的抑制效力。
