Nakamura M, Ohtaki S
Research Institute for Electronic Science, Hokkaido University.
Nihon Rinsho. 1994 Apr;52(4):857-63.
Thyroid peroxidase catalyzes the two-electron oxidations of tyrosine and monoiodotyrosine, and one-electron oxidation of diiodotyrosine. This difference in the oxidation, with tyrosine and diiodotyrosine, is also observed in the reaction of thyroid peroxidase with 0.2 and 0.7% iodine thyroglobulins. The results support the hypothesis that the increase in the diiodotyrosine residue in thyroglobulin inhibits further iodination by switching the catalytic cycle to oxidative coupling, to form thyroid hormones. Thyroid hormone synthesis requires iodide, H2O2, thyroglobulin and thyroid peroxidase. The stimulation of iodide uptake and H2O2 generation in the thyroid, as well as, protein synthesis of thyroglobulin and thyroid peroxidase in response to TSH has been reported. The regulation of thyroid hormone synthesis in the thyroid peroxidase reaction and through the peroxidase system is summarized.
甲状腺过氧化物酶催化酪氨酸和单碘酪氨酸的双电子氧化反应，以及二碘酪氨酸的单电子氧化反应。在甲状腺过氧化物酶与0.2%和0.7%碘甲状腺球蛋白的反应中，也观察到了酪氨酸和二碘酪氨酸氧化反应的这种差异。这些结果支持了这样一种假说，即甲状腺球蛋白中二碘酪氨酸残基的增加通过将催化循环切换到氧化偶联来抑制进一步的碘化反应，从而形成甲状腺激素。甲状腺激素的合成需要碘化物、过氧化氢、甲状腺球蛋白和甲状腺过氧化物酶。据报道，促甲状腺激素可刺激甲状腺对碘化物的摄取和过氧化氢的生成，以及甲状腺球蛋白和甲状腺过氧化物酶的蛋白质合成。本文总结了甲状腺过氧化物酶反应中以及通过过氧化物酶系统对甲状腺激素合成的调节。
