Baumgartner A, Campos-Barros A, Gaio U, Hessenius C, Flechner A, Meinhold H
Psychiatric Clinic, Universitätsklinikum Rudolf-Virchow, Berlin, Germany.
Life Sci. 1994;54(23):PL401-7. doi: 10.1016/0024-3205(94)90123-6.
The effects of subchronic administration of carbamazepine on thyroid hormone metabolism were investigated in the hippocampus in adult male rats at two different measuring times (4 a.m. and 8 p.m.). Carbamazepine enhanced the activity of 5'II-deiodinase, which catalyzes the deiodination of the prohormone T4 to the active compound T3, at 8 p.m., but not at 4 a.m. The activity of 5III-deiodinase, which catalyzes the further deiodination of the active hormone T3 to its metabolite 3,3'T2, was inhibited at 4 a.m. but not at 8 p.m. These effects of carbamazepine on intracellular thyroid hormone metabolism in the hippocampus should theoretically lead to a rise in T3 production. It remains to be investigated whether they are somehow involved in the as yet unknown mechanisms underlying the anticonvulsant/mood-stabilizing effects of carbamazepine.
在成年雄性大鼠的海马体中，于两个不同测量时间点（凌晨4点和晚上8点）研究了卡马西平亚慢性给药对甲状腺激素代谢的影响。卡马西平在晚上8点增强了5'II - 脱碘酶的活性，该酶催化激素原T4脱碘生成活性化合物T3，但在凌晨4点未出现这种情况。催化活性激素T3进一步脱碘生成其代谢物3,3'T2的5III - 脱碘酶活性在凌晨4点受到抑制，而在晚上8点未受抑制。卡马西平对海马体细胞内甲状腺激素代谢的这些影响理论上应导致T3生成增加。它们是否以某种方式参与卡马西平抗惊厥/情绪稳定作用背后尚不清楚的机制，仍有待研究。
