Benson B, Ebels I
Department of Anatomy, University of Arizona, Tucson.
Life Sci. 1994;54(24):PL437-43. doi: 10.1016/0024-3205(94)90153-8.
An antigonadotropic decapeptide was extracted from bovine pineal glands, purified by ultrafiltration and Sephadex G-25 gel-filtration chromatography and isolated by serial semi-preparative high performance liquid chromatography. Its primary structure was determined by automated amino acid and microsequence analyses. A synthetic analog of the decapeptide, prepared by solid state methods, was observed to reduce circulating levels of luteinizing hormone and prolactin after intra-atrial injection in male rats.
一种抗促性腺十肽从牛松果体中提取，经超滤和葡聚糖凝胶G - 25凝胶过滤色谱法纯化，并通过连续半制备高效液相色谱法分离。其一级结构通过自动氨基酸分析和微量序列分析确定。通过固态方法制备的该十肽的合成类似物，在雄性大鼠心房内注射后可降低促黄体生成素和催乳素的循环水平。
