Chance W T, Balasubramaniam A, Dayal R, Brown J, Fischer J E
Veterans Affairs Medical Center, Cincinnati, OH.
Life Sci. 1994;54(24):1869-74. doi: 10.1016/0024-3205(94)90144-9.
Hypothalamic concentration of neuropeptide Y was decreased significantly in anorectic tumor-bearing rats, while NPY level was increased significantly in matched carcass weight control rats as compared with freely-feeding controls. In vivo microdialysis of the perifornical hypothalamic area of tumor-bearing rats prior to the development of anorexia revealed no alteration in NPY in dialysates. Following the development of anorexia, however, tumor-bearing rats exhibited significant reduction in NPY concentration in dialysates as compared with either matched carcass weight or freely-feeding control group. These results suggest that hypothalamic NPY concentration and release are decreased selectively in anorectic tumor-bearing rats. Since NPY also elicits less feeding in tumor-bearing rats, dysfunction of hypothalamic NPY feeding mechanisms may be of primary importance in cancer anorexia.
厌食性荷瘤大鼠下丘脑神经肽Y的浓度显著降低，而与自由进食对照组相比，体重匹配的对照大鼠体内神经肽Y水平显著升高。在厌食症状出现之前，对荷瘤大鼠穹窿周下丘脑区域进行体内微透析，结果显示透析液中的神经肽Y没有变化。然而，在厌食症状出现后，与体重匹配或自由进食的对照组相比，荷瘤大鼠透析液中的神经肽Y浓度显著降低。这些结果表明，厌食性荷瘤大鼠下丘脑神经肽Y的浓度和释放选择性降低。由于神经肽Y也会减少荷瘤大鼠的进食，下丘脑神经肽Y进食机制的功能障碍可能在癌症厌食症中起主要作用。
