Labutta R J, Miles R B, Sanes J N, Hallett M
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892.
Mov Disord. 1994 Mar;9(2):218-22. doi: 10.1002/mds.870090217.
We used a delayed response paradigm to test the hypothesis that the prolonged reaction time in patients with Parkinson's disease (PD) is related to a deficiency in their ability to store a motor program in memory while waiting to move. PD patients, both on and off medication, were compared with age-matched normal subjects during arm movements directed toward a target light. The target light was displayed either during a 3- to 9-s delay or for only 1 s followed by a 2- to 8-s delay before the go signal. At the end of the delay, subjects were required to begin movement rapidly. The reaction time of PD patients was longer than normal and increased slightly when the patients were off medication. The patients had no excessive increase in reaction time with delay in either task compared with the control subjects. We conclude that patients with PD can hold a motor program in memory storage for at least 8 s.
帕金森病（PD）患者延长的反应时间与他们在等待行动时在记忆中存储运动程序的能力缺陷有关。在朝着目标光进行手臂运动期间，对正在服药和未服药的PD患者与年龄匹配的正常受试者进行了比较。目标光在发出开始信号前的3至9秒延迟期间显示，或者仅显示1秒，随后是2至8秒的延迟。在延迟结束时，要求受试者迅速开始运动。PD患者的反应时间比正常人长，并且在未服药时略有增加。与对照组相比，在任何一项任务中，患者的反应时间都不会因延迟而过度增加。我们得出结论，PD患者能够将运动程序存储在记忆中至少8秒。
