Copeland A, Lennon G
Human Genome Center, Lawrence Livermore National Laboratory, Livermore, California 94550.
Nature. 1994 Jun 2;369(6479):421-2. doi: 10.1038/369421a0.
By adapting a commercially available, general purpose laboratory robot, it is possible to produce high-density gridded hybridization filters of clone colonies or DNA products. We are using this system to produce 60-90, 8 x 12 cm filters in an 8-hour day, each containing 3,456 clones arranged in 96, 6 x 6 grids.
