Bednarczyk E M, Adler L P, Remler B, Goyer P, Wiznitzer M, Leisure G P, Little D, Miraldi F
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Pharmacotherapy. 1994 Mar-Apr;14(2):153-61.
The mechanism by which the fluorinated quinolones produce central nervous system effects is unknown. Using positron emission tomography (PET), we evaluated the effects of two quinolones on brain blood flow as well as on oxygen and glucose metabolism. These determinations were done in conjunction with ophthalmologic and neuro-ophthalmologic testing.
Randomized, double-blind, placebo-controlled, 7-day course of ciprofloxacin 750 mg (C750) or 500 mg (C500) every 12 hours, or nalidixic acid (NA) 1 g every 6 hours.
Twenty-four healthy male volunteers, six in each treatment arm.
[table: see text]
Compared with baseline values, NA significantly reduced brain glucose uptake, whereas C500, C750, and placebo produced no detectable effect. No compound significantly altered brain blood flow or oxygen metabolism compared with baseline or other treatments. No significant effect on electroretinographic, electro-oculographic, or other neuro-ophthalmologic tests was observed.
氟喹诺酮类药物产生中枢神经系统效应的机制尚不清楚。我们使用正电子发射断层扫描（PET）评估了两种喹诺酮类药物对脑血流以及氧和葡萄糖代谢的影响。这些测定与眼科和神经眼科检查同时进行。
随机、双盲、安慰剂对照，每12小时服用750毫克环丙沙星（C750）或500毫克（C500），或每6小时服用1克萘啶酸（NA），疗程7天。
24名健康男性志愿者，每个治疗组6人。
[表格：见正文]
与基线值相比，萘啶酸显著降低了脑葡萄糖摄取，而C500、C750和安慰剂未产生可检测到的影响。与基线或其他治疗相比，没有一种化合物能显著改变脑血流或氧代谢。在视网膜电图、眼电图或其他神经眼科检查中未观察到显著影响。
