Moldobaeva M S, Adambekov D A, Bestuzheva G R, Tikhonina S I, Abazbekova K T
Probl Endokrinol (Mosk). 1994 Mar-Apr;40(2):11-4.
Cellular nonspecific immunity was found reduced in residents of the lowlands and highlands suffering from alimentary obesity and noninsulin-dependent diabetes mellitus (NIDM), this depression augmenting with the increment of obesity degree and age of NIDM patients (p < 0.01-0.001). Activities of antihypoxic enzymes in these patients are drastically depressed under conditions of the highlands and do not depend on the patient's age. Lymphocyte killer activity in both patient populations is increased, more so in the highlands; this activity functionally or organically impairs insulin in the body forming with it immune complexes.
发现患有营养性肥胖症和非胰岛素依赖型糖尿病（NIDM）的低地和高地居民的细胞非特异性免疫降低，这种抑制随着肥胖程度的增加和NIDM患者年龄的增长而增强（p<0.01 - 0.001）。在高地条件下，这些患者的抗缺氧酶活性急剧下降，且与患者年龄无关。两组患者的淋巴细胞杀伤活性均增加，在高地更为明显；这种活性在功能上或有机地损害体内胰岛素，并与之形成免疫复合物。
