Oie B K, Myking O, Hoff P I, Ohm O J
Medical Department A, University School of Medicine, Haukeland Sykehus, Bergen, Norway.
Scand J Clin Lab Invest. 1994 Apr;54(2):155-9. doi: 10.3109/00365519409086522.
Atrial natriuretic peptide (ANP) was measured in coronary sinus (CS) plasma in seven patients with induced tachycardia. Right atrial pressure (RAP) and femoral artery (FA) levels of ANP, noradrenaline (NA) and adrenaline (A) were measured before and after 5 min with tachycardia. During tachycardia, ANP in CS plasma increased from 381 +/- 273 (mean +/- SD) to 1376 +/- 1191 pmol l-1 (p < 0.0001), and ANP levels in FA plasma from 89 +/- 48 to 231 +/- 151 pmol l-1 (p < 0.005). A significant increase was observed for peak RAP, whereas mean RAP remained unaltered. While no correlation existed between the increase in CS plasma ANP level and RAP, significant correlations were found between the changes in FA plasma ANP and RAP, and between FA plasma levels of ANP and NA. Following tachycardia, significant correlations were found both between ANP in CS and FA plasma and between the changes in these plasma levels. Whereas the changes in FA plasma levels of ANP during tachycardia seems dependent of RAP and arterial plasma levels of NA, the CS plasma ANP level appears to be independent of the two factors, probably because CS plasma ANP are drained mainly from the left side of the heart.
对7例诱发心动过速患者的冠状窦（CS）血浆中的心房利钠肽（ANP）进行了测定。在心动过速前及心动过速5分钟后，测量了右心房压力（RAP）以及ANP、去甲肾上腺素（NA）和肾上腺素（A）在股动脉（FA）中的水平。在心动过速期间，CS血浆中的ANP从381±273（均值±标准差）升高至1376±1191 pmol l-1（p<0.0001），FA血浆中的ANP水平从89±48升高至231±151 pmol l-1（p<0.005）。观察到RAP峰值显著升高，而平均RAP保持不变。虽然CS血浆ANP水平的升高与RAP之间不存在相关性，但FA血浆ANP的变化与RAP之间，以及FA血浆中ANP与NA水平之间存在显著相关性。心动过速后，CS和FA血浆中的ANP之间以及这些血浆水平的变化之间均发现显著相关性。虽然心动过速期间FA血浆中ANP水平的变化似乎依赖于RAP和动脉血浆中的NA水平，但CS血浆ANP水平似乎独立于这两个因素，这可能是因为CS血浆ANP主要从心脏左侧引流而来。
