Hasui Y, Osada Y, Kitada S, Nishi S
Department of Urology, Miyazaki Medical College, Japan.
Urology. 1994 Jun;43(6):782-6. doi: 10.1016/0090-4295(94)90134-1.
We tried to determine the significance of invasion to the muscularis mucosae on the progression of superficial bladder cancer.
We subclassified superficial bladder cancer showing lamina propria invasion into two groups: with (pT1b) or without cancer invasion to or near the muscularis mucosae (pT1a).
Of 164 bladder cancers, 76 showed no lamina propria invasion and 88 did. In the tumors with lamina propria invasion, 60 were diagnosed as pT1a and 28 as pT1b. The progression rate of pT1b cancer (53.5%) was significantly higher than that of pT1a cancer (6.7%) (P < 0.01). Regardless of size, number, or grade of tumor, the progression rate of pT1b cancer was significantly higher than that of pT1a cancer (P < 0.01).
We stress that patients with superficial cancer invading to or near the muscularis mucosae should be followed up carefully after transurethral resection.
我们试图确定侵犯黏膜肌层对浅表性膀胱癌进展的意义。
我们将显示固有层侵犯的浅表性膀胱癌分为两组：侵犯至黏膜肌层或其附近的（pT1b）和未侵犯的（pT1a）。
164例膀胱癌中，76例未显示固有层侵犯，88例显示有侵犯。在有固有层侵犯的肿瘤中，60例被诊断为pT1a，28例为pT1b。pT1b期癌的进展率（53.5%）显著高于pT1a期癌（6.7%）（P<0.01）。无论肿瘤的大小、数量或分级如何，pT1b期癌的进展率均显著高于pT1a期癌（P<0.01）。
我们强调，经尿道切除术后，对侵犯至黏膜肌层或其附近的浅表性癌患者应进行仔细随访。
