Grover-McKay M, Milne N, Atwood J E, Lyons K P
Cardiology Section, Long Beach Veterans Administration Medical Center.
Am Heart J. 1994 Jun;127(6):1516-20. doi: 10.1016/0002-8703(94)90379-4.
In patients who cannot perform treadmill exercise, both intravenous dipyridamole and arm exercise have been used with thallium-201 scintigraphy to detect significant coronary artery disease. However, no study has directly evaluated the results of intravenous dipyridamole and arm exercise thallium scintigraphy as compared with coronary angiography. It was the purpose of this study to compare intravenous dipyridamole and arm exercise thallium-201 single-photon emission computed tomographic (SPECT) scintigraphy for detection of significant coronary artery disease in patients who could not perform treadmill exercise. Data are presented for both intravenous dipyridamole and arm exercise thallium-201 SPECT scintigraphy in 18 men who could not perform treadmill exercise, and results are compared with those of coronary angiography. Ten of 11 (91%) patients with significant coronary artery disease were identified correctly, and the results of intravenous dipyridamole and arm exercise thallium scintigraphy were comparable. In patients without significant coronary artery disease, intravenous dipyridamole thallium images were interpreted correctly. However, initial arm exercise thallium images demonstrated a fixed inferior wall defect in two of seven patients without significant coronary artery disease. Images in one of these patients could not be retrieved from tape for further analysis. Review of the images in the other patient demonstrated relatively high background radioactivity, and when the images were displayed without background subtraction, the inferior wall was correctly interpreted as normal. We conclude that results of intravenous dipyridamole and arm exercise thallium-201 SPECT scintigraphy are comparable.
对于无法进行跑步机运动的患者，静脉注射双嘧达莫和手臂运动已与铊-201闪烁扫描术一起用于检测显著的冠状动脉疾病。然而，尚无研究直接评估静脉注射双嘧达莫和手臂运动铊闪烁扫描术与冠状动脉造影术相比的结果。本研究的目的是比较静脉注射双嘧达莫和手臂运动铊-201单光子发射计算机断层扫描（SPECT）闪烁扫描术在无法进行跑步机运动的患者中检测显著冠状动脉疾病的情况。本文给出了18名无法进行跑步机运动的男性患者静脉注射双嘧达莫和手臂运动铊-201 SPECT闪烁扫描术的数据，并将结果与冠状动脉造影术的结果进行比较。11名患有显著冠状动脉疾病的患者中有10名（91%）被正确识别，静脉注射双嘧达莫和手臂运动铊闪烁扫描术的结果具有可比性。在无显著冠状动脉疾病的患者中，静脉注射双嘧达莫铊图像被正确解读。然而，最初的手臂运动铊图像显示，7名无显著冠状动脉疾病的患者中有2名存在固定的下壁缺损。其中一名患者的图像无法从磁带上获取以进行进一步分析。对另一名患者图像的复查显示背景放射性相对较高，当不进行背景扣除显示图像时，下壁被正确解读为正常。我们得出结论，静脉注射双嘧达莫和手臂运动铊-201 SPECT闪烁扫描术的结果具有可比性。
