Shear P K, Jernigan T L, Butters N
Psychiatry Service, Department of Veterans Affairs Medical Center, Palo Alto, CA 94304.
Alcohol Clin Exp Res. 1994 Feb;18(1):172-6. doi: 10.1111/j.1530-0277.1994.tb00899.x.
Magnetic resonance imaging (MRI) of the brain was performed on a group of 24 recently detoxified, male alcoholics approximately 1 month after their date of last drink. The imaging was repeated 3 months later, at which point 9 subjects had resumed drinking and 15 had maintained abstinence. Contrasts between these two drinking groups revealed that, despite comparable baseline values, the Abstainers exhibited volumetric white matter increases and cerebrospinal fluid reductions over the follow-up interval, whereas the Drinkers did not show significant change on either of these MRI indices. These results provide the first evidence suggestive of significant volumetric white matter increase with abstinence.
对一组24名近期戒酒的男性酗酒者进行了脑部磁共振成像（MRI）检查，检查时间约为他们最后一次饮酒日期后的1个月。3个月后重复成像，此时9名受试者恢复饮酒，15名保持戒酒。这两个饮酒组之间的对比显示，尽管基线值相当，但在随访期间，戒酒者的白质体积增加，脑脊液减少，而饮酒者在这两个MRI指标上均未显示出显著变化。这些结果首次提供了证据，表明戒酒会使白质体积显著增加。
