Messora C, Bensi L, Vecchi A, Longo R, Giacobbi F, Temperani P, Bevini M, Emilia G, Sacchi S
Istituto di Clinica Medica II, Università di Modena, Italy.
Br J Haematol. 1994 Feb;86(2):402-4. doi: 10.1111/j.1365-2141.1994.tb04752.x.
Polycythaemia vera is a clonal disorder of the haemopoietic stem cell causing a pathologic expansion of the erythroid and sometimes the megakaryocytic and myeloid elements. In order to avoid the possible mutagenic effects of radioactive phosphorus, alkylating agents and hydroxyurea, since 1988 alpha-IFN has been used for the treatment of PV and has been shown to induce and maintain haematological remission. We describe a 24-year-old PV patient with chromosomal abnormalities who achieved not only a reduction of the proliferation of erythroid elements and reticulin content in the bone marrow, but also a complete cytogenetic remission after IFN treatment.
真性红细胞增多症是一种造血干细胞的克隆性疾病，可导致红系，有时还有巨核系和髓系成分的病理性增生。为避免放射性磷、烷化剂和羟基脲可能产生的诱变作用，自1988年以来，α-干扰素已被用于治疗真性红细胞增多症，并已显示可诱导和维持血液学缓解。我们描述了一名患有染色体异常的24岁真性红细胞增多症患者，该患者在接受干扰素治疗后不仅红系细胞增殖和骨髓网硬蛋白含量降低，而且实现了完全细胞遗传学缓解。
