Gordon D B
Lancet. 1978 Nov 4;2(8097):970-2. doi: 10.1016/s0140-6736(78)92531-x.
The hypothesis that increased plasma-renin tends to lower blood-pressure is proposed. Binding of renin to blood-vessel walls is postulated to have some vasodilator action which would oppose the usual blood-pressure-raising action caused by generation of angiotensin. Many of the effects of saralasin and of converting-enzyme inhibitor on blood-pressure in relation to concentrations of renin in blood plasma and in the kidneys seem to support this hypothesis.
有人提出血浆肾素增加往往会降低血压这一假说。假定肾素与血管壁的结合具有某种血管舒张作用，这会对抗由血管紧张素生成所引起的常见血压升高作用。沙拉新和转化酶抑制剂对血压的许多影响，与血浆和肾脏中肾素浓度的关系，似乎都支持这一假说。
