Xu X J, Hökfelt T, Hughes J, Wiesenfeld-Hallin Z
Department of Laboratory Medical Science and Technology, Karolinska Institute, Huddinge University Hospital, Sweden.
Neuroreport. 1994 Feb 24;5(6):718-20. doi: 10.1097/00001756-199402000-00015.
We have examined and compared the effect of systemic CI988, an antagonist of the cholecystokinin B receptor, and morphine on the flexor reflex in rats with intact sciatic nerves and after unilateral axotomy. Intravenous injection of 1 mg kg-1 morphine caused a moderate depression of the flexor reflex in normal and axotomized rats. The duration of morphine-induced depression was significantly shortened in axotomized animals. In contrast, the brief depressive effect of intravenous CI988 on the flexor reflex was significantly enhanced in axotomized rats. Combination of morphine and CI988 resulted in a significant potentiation of reflex depression in rats with intact or sectioned sciatic nerves. It is concluded that blockade of CCK-B receptor potentiated morphine-induced antinociception in rats after peripheral nerve injury.
我们研究并比较了胆囊收缩素B受体拮抗剂全身性CI988和吗啡对坐骨神经完整及单侧轴突切断术后大鼠屈肌反射的影响。静脉注射1 mg/kg吗啡会使正常和轴突切断的大鼠屈肌反射出现中度抑制。在轴突切断的动物中，吗啡诱导的抑制持续时间显著缩短。相比之下，静脉注射CI988对屈肌反射的短暂抑制作用在轴突切断的大鼠中显著增强。吗啡和CI988联合使用会使坐骨神经完整或切断的大鼠反射抑制显著增强。得出的结论是，在周围神经损伤后，阻断CCK-B受体可增强大鼠吗啡诱导的镇痛作用。
