Wood M, Stambler B, Ellenbogen K
Medical College of Virginia, Richmond.
Curr Opin Cardiol. 1994 Jan;9(1):3-11. doi: 10.1097/00001573-199401000-00002.
After more than 20 years of clinical use, programmed electrical stimulation for induction of cardiac arrhythmias remains an important clinical and research tool. The procedure continues to undergo refinement but is not without controversy regarding its accuracy in predicting drug efficacy as determined by serial testing for suppression of ventricular tachyarrhythmias. Recent work has streamlined technical aspects of the procedure itself and promises to improve the selection of patients likely to benefit from such studies. Despite these advances, however, recent publications from the Electrophysiologic Study Versus Electrocardiographic Monitoring trial raise fundamental questions about the ability of any current strategy to predict the efficacy of antiarrhythmic drugs for the prevention of ventricular arrhythmias.
经过20多年的临床应用，用于诱发心律失常的程控电刺激仍然是一项重要的临床和研究工具。该程序仍在不断完善，但在通过连续测试抑制室性快速心律失常来确定其预测药物疗效的准确性方面存在争议。最近的工作简化了该程序本身的技术环节，并有望改善对可能从这类研究中获益的患者的选择。然而，尽管有这些进展，电生理研究与心电图监测试验最近发表的文章对目前任何预测抗心律失常药物预防室性心律失常疗效的策略的能力提出了根本性问题。
