Jeannin P, Delneste Y, Tillie-Leblond I, Wallaert B, carlier A, Pestel J, Tonnel A B
CJF Inserm 90-06, Institut Pasteur, Lille, France.
Int Arch Allergy Immunol. 1994;104(2):191-8. doi: 10.1159/000236729.
Various studies have suggested the involvement of immunoglobulin G4 (IgG4) antibodies (Ab) in the physiopathology of allergic disorders. Recently, an abnormal IgG4 Ab production in response to immunization has been reported in some atopic patients. Thus, in order to evidence in allergic patients, a potential abnormal IgG4 Ab response to aeroallergens following natural exposure, we compared, in 34 patients sensitive to Dermatophagoides pteronyssinus and in 16 healthy subjects, the IgG4 Ab response to D. pteronyssinus, grass pollen and cat dander, using a solid-phase radioimmunoassay. Since some patients were also sensitive to grass pollen and/or to cat dander, we analyzed, in all patients, the IgG4 Ab responses both towards the allergen(s) they were sensitive to (sensitizing allergen) or not (unrelated allergen). The results showed that 90% of the patients produced levels of antisensitizing allergen(s) IgG4 Ab significantly higher than the controls; this IgG4 Ab response was correlated with the corresponding specific IgE Ab level. In addition, among these patients, around 40% presented high levels of IgG4 Ab to the unrelated allergen(s). Thus, in allergic patients, while specific IgE Ab define the nature of the sensitizing allergen, the presence of IgG4 Ab directed against various allergens seems in relation with an abnormal isotype regulation associated with atopic disorders.
多项研究表明免疫球蛋白G4（IgG4）抗体（Ab）参与了过敏性疾病的病理生理过程。最近，有报道称一些特应性患者在免疫接种后出现异常的IgG4 Ab产生。因此，为了证明过敏性患者在自然暴露后对气传变应原潜在的异常IgG4 Ab反应，我们使用固相放射免疫分析法比较了34名对尘螨过敏的患者和16名健康受试者对尘螨、草花粉和猫毛屑的IgG4 Ab反应。由于一些患者也对草花粉和/或猫毛屑敏感，我们分析了所有患者对他们敏感的变应原（致敏变应原）和不敏感的变应原（无关变应原）的IgG4 Ab反应。结果显示，90%的患者产生的抗致敏变应原IgG4 Ab水平显著高于对照组；这种IgG4 Ab反应与相应的特异性IgE Ab水平相关。此外，在这些患者中，约40%对无关变应原产生高水平的IgG4 Ab。因此，在过敏性患者中，虽然特异性IgE Ab确定了致敏变应原的性质，但针对各种变应原的IgG4 Ab的存在似乎与特应性疾病相关的异常同种型调节有关。
