Tamura T, Kanamori H, Yamazaki E, Ohtsuka M, Hataoka K, Maeda K, Okamoto R, Tanabe J, Fujita H, Hashimoto Y
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Bone Marrow Transplant. 1994 Mar;13(3):321-3.
We describe a case of cold agglutinin disease (CAD) following allogeneic bone marrow transplantation. This 36-year-old male developed CAD 3 weeks after allogeneic bone marrow transplantation for chronic myelogenous leukemia. Cyclosporin A and methotrexate had been administered to prevent graft-versus-host disease. Other agents administered included cytomegalovirus hyperimmune globulin and recombinant human G-CSF. Pericarditis preceded the development of CAD. The characterization of cold agglutinin (CA) was monoclonal IgM-kappa with anti-Pr antigen specificity, probably derived from the engrafted donor lymphocytes. The administration of prednisolone led to transient improvement. The CA titer decreased without further treatment 12 weeks after transplant.
我们描述了一例异基因骨髓移植后发生冷凝集素病（CAD）的病例。这名36岁男性在接受异基因骨髓移植治疗慢性粒细胞白血病3周后发生了CAD。已给予环孢素A和甲氨蝶呤以预防移植物抗宿主病。其他给予的药物包括巨细胞病毒高效价免疫球蛋白和重组人粒细胞集落刺激因子。心包炎先于CAD出现。冷凝集素（CA）的特征为具有抗-Pr抗原特异性的单克隆IgM-κ，可能来源于植入的供体淋巴细胞。泼尼松龙治疗导致病情短暂改善。移植后12周未进一步治疗，CA滴度下降。
