Ohashi K, Akiyama H, Takamoto S, Tanikawa S, Sakamaki H, Onozawa Y
Department of Hematology, Tokyo Metropolitan Komagome Hospital, Japan.
Bone Marrow Transplant. 1994 Mar;13(3):335-6.
A case of pure red cell aplasia after major ABO-incompatible bone marrow transplantation with long duration of up to 482 days is presented. The patient exhibited resistance to treatment using intravenous gamma globulin, prednisolone and 8 week administration of erythropoietin. The patient finally responded to treatment using erythropoietin and methylprednisolone simultaneously. Because of its safety and efficacy, it might be worthwhile to try erythropoietin with methylprednisolone, if necessary, for pure red cell aplasia complicating major ABO-incompatible bone marrow transplantation.
本文报告1例主要ABO血型不合骨髓移植后发生的纯红细胞再生障碍性贫血，病程长达482天。患者对静脉注射丙种球蛋白、泼尼松龙及8周促红细胞生成素治疗均耐药。该患者最终对促红细胞生成素与甲泼尼龙联合治疗产生反应。因其安全性及有效性，对于主要ABO血型不合骨髓移植并发的纯红细胞再生障碍性贫血，如有必要，尝试促红细胞生成素与甲泼尼龙联合治疗可能是值得的。
