Russell J, Allen B, Mira M, Vizzard J, Stewart P, Beumont P
Department of Psychiatry, University of Sydney, NSW, Australia.
Int J Eat Disord. 1994 Apr;15(3):275-8. doi: 10.1002/1098-108x(199404)15:3<275::aid-eat2260150311>3.0.co;2-9.
It has been demonstrated that clinical outcome is positively correlated with depletion of total body nitrogen (TBN) and therefore of body protein in certain serious medical conditions such as cystic fibrosis or patients receiving dialysis for chronic renal failure. Patients with anorexia nervosa are not suffering from medical illness per se yet the illness can be chronic and severely debilitating requiring numerous hospitalizations for refeeding and/or management of medical complications. The prediction of chronicity remains an important and difficult issue that this study seeks to address by examining the correlation between several clinical indices in 18 patients suffering from anorexia nervosa with parameters of body composition, namely TBN and percentage body fat. TBN was measured using the technique of in vivo neutron-activation analysis (IVNAA) and expressed as nitrogen index. Percentage body fat was estimated using skinfold measurements. The highest correlation was between nitrogen index and number of hospitalizations (r = -.80). The data support a relationship between depletion of body nitrogen/protein and chronicity in anorexia nervosa.
业已证明，在某些严重的医学病症（如囊性纤维化或接受慢性肾衰竭透析的患者）中，临床结果与全身氮（TBN）的消耗以及身体蛋白质的消耗呈正相关。神经性厌食症患者本身并非患有医学疾病，但这种疾病可能是慢性的且严重使人衰弱，需要多次住院进行重新喂食和/或处理医学并发症。慢性化的预测仍然是一个重要且困难的问题，本研究试图通过检查18例神经性厌食症患者的几个临床指标与身体成分参数（即TBN和体脂百分比）之间的相关性来解决这一问题。使用体内中子活化分析（IVNAA）技术测量TBN，并表示为氮指数。使用皮褶测量法估计体脂百分比。氮指数与住院次数之间的相关性最高（r = -0.80）。数据支持神经性厌食症中身体氮/蛋白质消耗与慢性化之间的关系。
