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人绒毛膜促性腺激素（HCG）的异位产生：通过血清分析检测膀胱移行细胞癌中HCG的临床相关性如何？

Ectopic human chorionic gonadotrophin (HCG) production: is the detection by serum analysis of HCG of clinical relevance in transitional cell carcinoma of the bladder?

作者信息

Smith D J, Evans H J, Newman J, Chapple C R

机构信息

Department of Urology, Royal Hallamshire Hospital, Sheffield, UK.

出版信息

Br J Urol. 1994 Apr;73(4):409-12. doi: 10.1111/j.1464-410x.1994.tb07605.x.

DOI:10.1111/j.1464-410x.1994.tb07605.x
PMID:8199829
Abstract

OBJECTIVE

To assess the potential value of ectopic beta-human chorionic gonadotrophin (beta HCG) measurement in the clinical management of transitional cell carcinoma (TCC).

PATIENTS AND METHODS

A prospective serological study of 163 consecutive patients undergoing cystoscopy as new or review cases was performed to assess any correlation between beta HCG production and histological grading or stage.

RESULTS

Ten per cent of patients with TCC had a raised beta HCG level but there was no correlation with tumour differentiation, staging or prognosis.

CONCLUSIONS

beta HCG has no role as a tumour marker for TCC and therefore appears unlikely to play a part in the clinical management or treatment of urothelial tumours.

摘要

目的

评估异位β-人绒毛膜促性腺激素（β-HCG）检测在移行细胞癌（TCC）临床管理中的潜在价值。

患者与方法

对163例因初次就诊或复诊而接受膀胱镜检查的患者进行了一项前瞻性血清学研究，以评估β-HCG产生与组织学分级或分期之间的相关性。

结果

10%的TCC患者β-HCG水平升高，但与肿瘤分化、分期或预后无关。

结论

β-HCG不作为TCC的肿瘤标志物，因此似乎不太可能在尿路上皮肿瘤的临床管理或治疗中发挥作用。

相似文献

1
Ectopic human chorionic gonadotrophin (HCG) production: is the detection by serum analysis of HCG of clinical relevance in transitional cell carcinoma of the bladder?人绒毛膜促性腺激素（HCG）的异位产生：通过血清分析检测膀胱移行细胞癌中HCG的临床相关性如何？
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Prognostic value of beta human chorionic gonadotrophin in blood serum of patients with urinary bladder tumours.β-人绒毛膜促性腺激素在膀胱肿瘤患者血清中的预后价值
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Serum and urinary levels of beta human chorionic gonadotrophin in patients with transitional cell carcinoma.移行细胞癌患者血清和尿液中的β-人绒毛膜促性腺激素水平。
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Is beta-human chorionic gonadotrophin production by transitional cell carcinoma of the bladder a marker of aggressive disease and resistance to radiotherapy?膀胱移行细胞癌产生的β-人绒毛膜促性腺激素是否是侵袭性疾病和放疗抵抗的标志物？
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The expression of beta human chorionic gonadotrophin (β-HCG) in human urothelial carcinoma.β-人绒毛膜促性腺激素（β-HCG）在人尿路上皮癌中的表达。
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Br J Urol. 1989 Sep;64(3):241-4. doi: 10.1111/j.1464-410x.1989.tb06006.x.

引用本文的文献

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The expression of beta human chorionic gonadotrophin (β-HCG) in human urothelial carcinoma.β-人绒毛膜促性腺激素（β-HCG）在人尿路上皮癌中的表达。
Pan Afr Med J. 2010;7:20. Epub 2010 Dec 16.
3
[Urothelium cancer with trophoblastic differentiation. An unusual case of a 77 year old patient].[伴有滋养层分化的尿路上皮癌。一名77岁患者的罕见病例]
Urologe A. 2006 Jan;45(1):81-4. doi: 10.1007/s00120-005-0953-y.
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Bladder tumor markers: need, nature and application. 2. Tumor and tumor-associated antigens.膀胱肿瘤标志物：需求、性质与应用。2. 肿瘤及肿瘤相关抗原。
Int Urogynecol J Pelvic Floor Dysfunct. 1998;9(4):228-35. doi: 10.1007/BF01901609.
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Different hCG assays to measure ectopic hCG secretion in bladder carcinoma patients.用于测量膀胱癌患者异位人绒毛膜促性腺激素（hCG）分泌的不同hCG检测方法。
Br J Cancer. 1996 Oct;74(7):1081-4. doi: 10.1038/bjc.1996.493.
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The effects of beta-human chorionic gonadotrophin on the in vitro growth of bladder cancer cell lines.β-人绒毛膜促性腺激素对膀胱癌细胞系体外生长的影响。
Br J Cancer. 1996 Feb;73(3):323-6. doi: 10.1038/bjc.1996.56.