Nishiyama T, Washiyama K, Tanikawa T, Mineyama H, Sasagawa T, Susuki H, Kitamura Y, Sato S
Department of Urology, Niigata University School of Medicine, Japan.
Urol Int. 1992;48(4):463-5. doi: 10.1159/000282380.
We report a patient with gynecomastia and ectopic production of human chorionic gonadotropin (HCG) by a transitional cell carcinoma of the bladder. In the present case, serum HCG levels and gynecomastia paralleled the clinical course. On admission, the patient was suffering from invasive transitional cell carcinoma (grade 3) of the bladder with metastasis to the left inguinal lymph nodes, together with gynecomastia. The serum HCG level was also elevated. After anticancer chemotherapy, the apparent bladder lesion and gynecomastia disappeared, and the serum HCG level declined to within normal limits. About 2 months after discharge, when the patient suffered from recurrent invasive tumors of the bladder, gynecomastia reappeared and the serum HCG level again became elevated. beta-HCG was demonstrated in biopsy tissue using the immunoperoxidase technique. The presence of beta-HCG was always focally demonstrated and was shown to be localized in the cytoplasm of the tumor cells.
我们报告了一例患有男性乳房发育症且膀胱移行细胞癌异位分泌人绒毛膜促性腺激素（HCG）的患者。在本病例中，血清HCG水平和男性乳房发育症与临床病程平行。入院时，患者患有膀胱浸润性移行细胞癌（3级）并伴有左腹股沟淋巴结转移，同时伴有男性乳房发育症。血清HCG水平也升高。抗癌化疗后，明显的膀胱病变和男性乳房发育症消失，血清HCG水平降至正常范围内。出院后约2个月，当患者出现膀胱复发性浸润性肿瘤时，男性乳房发育症再次出现，血清HCG水平再次升高。使用免疫过氧化物酶技术在活检组织中检测到β-HCG。β-HCG的存在始终呈局灶性显示，并显示定位于肿瘤细胞的细胞质中。
