Mortensen H B, Hougaard P, Ibsen K K, Parving H H
Department of Paediatrics, Glostrup Hospital, Denmark.
Diabet Med. 1994 Mar;11(2):155-61. doi: 10.1111/j.1464-5491.1994.tb02012.x.
In 1989 a nation-wide investigation of blood pressure and urinary albumin excretion rate (AER) was carried out in 506 boys and 441 girls with Type 1 diabetes (approximately 80% of total) treated at 22 paediatric departments. In addition a reference population from 1979 consisting of 663 healthy non-diabetic children (334 boys, 329 girls) served as a control group with respect to blood pressure and body mass index. Microalbuminuria was defined as AER of 20-150 micrograms min-1 in at least two out of three timed overnight urine collections and was diagnosed in 30 adolescents (16 boys, 14 girls). Five patients (3 boys, 2 girls) had overt proteinuria (AER: > 150 micrograms min-1). Age-related percentile charts based on one blood pressure reading were provided for normoalbuminuric diabetic patients and the healthy control group. The study revealed an increase in arterial blood pressure during the period of the pubertal growth spurt for the diabetic and non-diabetic group. The changes were most pronounced for systolic blood pressure. No statistically significant difference was observed in systolic and diastolic blood pressure between normoalbuminuric diabetic children and healthy control children. However, diabetic females aged 15-18 years had significantly higher diastolic blood pressure (75 +/- 1 mmHg, n = 139, mean +/- SE) than healthy control females (72 +/- 1 mmHg, n = 155, p < 0.01), and significantly (p < 0.001) higher body mass index (diabetic females: 22.3 +/- 0.2 kg m-2 vs healthy females: 20.9 +/- 0.2 kg m-2, mean +/- SE.(ABSTRACT TRUNCATED AT 250 WORDS)
1989年，在22个儿科部门对506名患1型糖尿病的男孩和441名患1型糖尿病的女孩（约占总数的80%）进行了一项关于血压和尿白蛋白排泄率（AER）的全国性调查。此外，1979年的一个由663名健康非糖尿病儿童（334名男孩，329名女孩）组成的参照人群作为血压和体重指数的对照组。微量白蛋白尿的定义为在三次定时夜间尿液收集样本中至少两次的AER为20 - 150微克/分钟，30名青少年（16名男孩，14名女孩）被诊断为微量白蛋白尿。5名患者（3名男孩，2名女孩）有显性蛋白尿（AER：> 150微克/分钟）。为正常白蛋白尿的糖尿病患者和健康对照组提供了基于一次血压读数的年龄相关百分位数图表。该研究显示，糖尿病组和非糖尿病组在青春期生长突增期间动脉血压升高。收缩压的变化最为明显。正常白蛋白尿的糖尿病儿童与健康对照儿童在收缩压和舒张压方面未观察到统计学上的显著差异。然而，15 - 18岁的糖尿病女性的舒张压（75±1 mmHg，n = 139，平均值±标准误）显著高于健康对照女性（72±1 mmHg，n = 155，p < 0.01），且体重指数显著更高（p < 0.001）（糖尿病女性：22.3±0.2 kg/m²，健康女性：20.9±0.2 kg/m²，平均值±标准误）。（摘要截短于250字）
