Vaz M, Kulkarni R N, Leo L, Shetty P S
Department of Physiology, St John's Medical College, Bangalore, India.
Eur J Clin Nutr. 1994 Jan;48(1):30-7.
Twelve healthy adults divided into a well-nourished (WN; n = 6) and a chronically energy deficient (CED; n = 6) groups underwent a single 30 min infusion of norepinephrine (NE) administered at the rate of 0.15 micrograms/kg fat-free mass/min. Measured parameters in the basal state and during the infusion included heart rate (by electrocardiograph), stroke volume, cardiac output and other cardiac indices (by impedance cardiography) and blood pressure recordings. The data are suggestive of fairly similar cardiovascular responses in the CED and WN subjects, with the exception of cardiac inotropy (i.e. strength of cardiac muscle contractility) and changes in total peripheral resistance, both of which were enhanced in the CED. Peak NE levels of both groups during the infusion were similar and so was the clearance rate for NE corrected for fat-free mass differences. Although plasma half-life of NE tended to be higher in the CED group, plasma appearance rates of NE were comparable between the groups, suggesting that plasma NE kinetics were not altered in CED adults.
12名健康成年人被分为营养良好组（WN；n = 6）和慢性能量缺乏组（CED；n = 6），以0.15微克/千克去脂体重/分钟的速率接受单次30分钟的去甲肾上腺素（NE）输注。基础状态和输注期间测量的参数包括心率（通过心电图）、每搏输出量、心输出量和其他心脏指数（通过阻抗心动图）以及血压记录。数据表明，CED组和WN组的心血管反应相当相似，但心肌收缩力（即心肌收缩强度）和总外周阻力的变化除外，这两者在CED组中均增强。输注期间两组的NE峰值水平相似，校正去脂体重差异后的NE清除率也相似。虽然CED组中NE的血浆半衰期倾向于更高，但两组之间NE的血浆出现率相当，表明CED成年人的血浆NE动力学没有改变。
