Gilja I, Parazajder J, Radej M, Cvitković P, Kovacić M
Department of Urology, General Hospital (Sveti Duh), Zagreb, Croatia.
Eur Urol. 1994;25(3):226-8. doi: 10.1159/000475288.
Twenty-five patients with retrograde ejaculation/loss of emission were treated with ephedrine sulfate or imipramine hydrochloride. Seventeen of them suffering from both diabetes and retrograde ejaculation were treated with ephedrine or, in case that ephedrine failed to convert retrograde ejaculation into anterograde ejaculation, with imipramine. Positive results were obtained in 5/17 (29.3%) patients, i.e. in 3 (17.6%) and 2 (11.7%) patients on ephedrine and imipramine, respectively. The daily dose of ephedrine was 50 mg and that of imipramine 75 mg, during a 4-week period. In the group with retroperitoneal lymphadenectomy, after treatment with ephedrine, only 1 (12.5%) had retrograde ejaculation while the remaining patients (n = 7) continued to lack semen emission. These 7 patients were treated with imipramine, and 3 of them (42.8%) achieved anterograde ejaculation. In one third of patients with retroperitoneal lymphadenectomy and diabetes, with retrograde ejaculation or loss of semen emission, conservative treatment can offer improvement or conversion to anterograde ejaculation.
25例逆行射精/射精无力患者接受了硫酸麻黄碱或盐酸丙咪嗪治疗。其中17例同时患有糖尿病和逆行射精的患者接受了麻黄碱治疗，若麻黄碱未能将逆行射精转变为顺行射精，则接受丙咪嗪治疗。17例患者中有5例（29.3%）获得了阳性结果，即分别有3例（17.6%）和2例（11.7%）患者使用麻黄碱和丙咪嗪治疗有效。在为期4周的治疗期间，麻黄碱的日剂量为50mg，丙咪嗪为75mg。在接受腹膜后淋巴结清扫术的患者组中，使用麻黄碱治疗后，只有1例（12.5%）存在逆行射精，其余患者（n = 7）仍无精液射出。这7例患者接受了丙咪嗪治疗，其中3例（42.8%）实现了顺行射精。在三分之一接受腹膜后淋巴结清扫术且患有糖尿病、存在逆行射精或无精液射出的患者中，保守治疗可使病情改善或转变为顺行射精。
