Lindner H, Kleinebudde P
Department of Pharmaceutics and Biopharmaceutics, Christian-Albrecht-University, Kiel, Germany.
J Pharm Pharmacol. 1994 Jan;46(1):2-7. doi: 10.1111/j.2042-7158.1994.tb03710.x.
The use of powdered cellulose instead of microcrystalline cellulose in the extrusion/spheronization process was investigated. The aim of the study was to assess differences between two types of powdered cellulose using a 2(4-1) fractional factorial design. Water content and amount of binder were found to be most important while type of cellulose and screw speed had only negligible influence on the extrusion process and the resulting pellets. Pellets obtained with powdered celluloses showed higher porosities and faster dissolution rates compared with those made with microcrystalline cellulose. Image analysis was found to be an appropriate method for the simultaneous characterization of pellet size and shape.
研究了在挤出/滚圆工艺中使用粉状纤维素代替微晶纤维素的情况。本研究的目的是使用2(4 - 1)部分因子设计评估两种粉状纤维素之间的差异。发现含水量和粘合剂用量最为重要，而纤维素类型和螺杆速度对挤出过程及所得颗粒的影响可忽略不计。与用微晶纤维素制成的颗粒相比，用粉状纤维素获得的颗粒具有更高的孔隙率和更快的溶解速率。图像分析被认为是同时表征颗粒尺寸和形状的合适方法。
