[利用三羰基芳烃铬配合物开发高选择性合成方法及其在治疗剂合成中的应用]
[Development of highly selective synthetic methods utilizing arenetricarbonylchromium complexes and their application to syntheses of therapeutic agents].
作者信息
Sodeoka M
机构信息
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Yakugaku Zasshi. 1994 Apr;114(4):219-32. doi: 10.1248/yakushi1947.114.4_219.
The development of new methodologies for the stereocontrolled synthesis of complex molecules is very important for the efficient synthesis of therapeutic agents. In this review, 1) the stereocontrolled synthesis of exocyclic olefins using arene.Cr(CO)3-catalyzed 1,4-hydrogenation of conjugated diene and its application to the synthesis of prostacyclin analogs, 2) new catalytic activities of arene.Cr(CO)3 as a hydrogenation catalyst, 3) the stereocontrolled synthesis of silyl dienol ethers and dienamides using arene.Cr(CO)3-catalyzed isomerization, and 4) a novel carbon-carbon bond-forming reaction through eta 5-pentadienylchromium complexes, are described.
开发用于立体控制合成复杂分子的新方法对于高效合成治疗药物非常重要。在本综述中，描述了以下内容：1）使用芳烃·Cr(CO)₃催化共轭二烯的1,4-氢化反应对外环烯烃进行立体控制合成及其在前列环素类似物合成中的应用；2）芳烃·Cr(CO)₃作为氢化催化剂的新催化活性；3）使用芳烃·Cr(CO)₃催化异构化反应对甲硅烷基二烯醇醚和二烯酰胺进行立体控制合成；4）通过η⁵-戊二烯基铬配合物进行的新型碳-碳键形成反应。
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