重新审视大肠杆菌K12组氨酸操纵子的核苷酸序列。

Nucleotide sequence of the Escherichia coli K12 histidine operon revisited.

作者信息

Jovanović G, Kostić T, Janković M, Savić D J

机构信息

Institute of Molecular Genetics and Genetic Engineering, Belgrade, Yugoslavia.

出版信息

J Mol Biol. 1994 Jun 10;239(3):433-5. doi: 10.1006/jmbi.1994.1384.

DOI:10.1006/jmbi.1994.1384

Abstract

We report on a significant difference between the published nucleotide sequence of the Escherichia coli K12 histidine operon and our sequencing results repeatedly obtained from a number of different E. coli K12 strains. The discrepancies include 39 base-pair changes and one addition located predominantly in the proximal portion of the operon. Our data also suggest that neutral and near-neutral mutations do not accumulate to a significant extent in the histidine operon of E. coli strains harbouring strong mutator alleles.

摘要

我们报告了大肠杆菌K12组氨酸操纵子已发表的核苷酸序列与我们多次从多个不同大肠杆菌K12菌株获得的测序结果之间的显著差异。差异包括39个碱基对的变化和1个插入，主要位于操纵子的近端部分。我们的数据还表明，在携带强诱变等位基因的大肠杆菌菌株的组氨酸操纵子中，中性和近中性突变不会大量积累。

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