Nitti V W, Raz S
Division of Urology, University of California School of Medicine, Los Angeles.
J Urol. 1994 Jul;152(1):93-8. doi: 10.1016/s0022-5347(17)32825-2.
We reviewed the charts of 41 patients who underwent transvaginal urethrolysis and resuspension of the bladder neck by the Raz technique for urethral obstruction with or without stress urinary incontinence following anti-incontinence surgery. We sought to evaluate the effectiveness of the procedure as well as to determine any factors that had an effect on the outcome of surgery. Patients were evaluated for obstruction and stress urinary incontinence by history, physical examination, video urodynamics (or multichannel urodynamics plus cystogram and voiding cystourethrography) and cystoscopy. All patients reported normal emptying before the procedure that caused obstruction. Several variables were evaluated for individual predictive values for outcome, including type of surgery causing obstruction, number of previous anti-incontinence procedures, urodynamic evidence of obstruction (high pressure, low flow), instability, concomitant stress urinary incontinence and total urinary retention, which were evaluated by the Fisher exact test, and the amount of post-void residual, bladder capacity, maximum detrusor pressure, maximum urinary flow and interval since surgery causing obstruction, which were evaluated by logistic regression analysis. Mean patient age was 59 years (range 26 to 86 years) and mean followup was 21 months. A total of 19 patients (46%) suffered from concurrent stress urinary incontinence, 23 (56%) had urodynamic evidence of obstruction (high pressure/low flow) and 6 (15%) had only radiographic or endoscopic evidence with a deviated or kinked urethra. Postoperatively, 29 patients (71%) voided normally without significant residuals. Eight patients (20%) remain on self-catheterization and 1 has persistent stress urinary incontinence. When individual variables were evaluated to determine the predictive values with respect to outcome of urethrolysis, only the preoperative post-void residual was statistically significant (the greater the post-void residual, the more likely was failure, p = 0.021). The presence or strength of the detrusor contraction preoperatively and pressure-flow analysis did not predict outcome. Of the patients with stress urinary incontinence 15 (79%) were cured and 3 (16%) were significantly improved with rare stress urinary incontinence not requiring protection. Overall, 33 patients (80%) had some benefit from surgery. Patients who emptied normally before and anti-incontinence procedure that causes obstruction or impaired emptying should not be excluded from urethrolysis based on low detrusor pressures or pressure-flow analysis alone. Simultaneous radiographic imaging and endoscopy may help to select certain patients with obstruction.
我们回顾了41例接受经阴道尿道松解术并采用Raz技术行膀胱颈悬吊术的患者病历,这些患者因抗尿失禁手术后出现尿道梗阻伴或不伴压力性尿失禁。我们试图评估该手术的有效性,并确定影响手术结果的任何因素。通过病史、体格检查、影像尿动力学检查(或多通道尿动力学检查加膀胱造影和排尿性膀胱尿道造影)以及膀胱镜检查对患者的梗阻和压力性尿失禁情况进行评估。所有患者在导致梗阻的手术前均报告排尿正常。对几个变量进行了个体预后预测价值评估,包括导致梗阻的手术类型、既往抗尿失禁手术的次数、梗阻的尿动力学证据(高压、低流量)、不稳定性、伴发的压力性尿失禁和完全性尿潴留,通过Fisher精确检验进行评估;以及排尿后残余尿量、膀胱容量、最大逼尿肌压力、最大尿流率和自导致梗阻的手术以来的时间间隔,通过逻辑回归分析进行评估。患者平均年龄为59岁(范围26至86岁),平均随访时间为21个月。共有19例患者(46%)并发压力性尿失禁,23例(56%)有梗阻的尿动力学证据(高压/低流量),6例(15%)仅有尿道偏斜或扭曲的影像学或内镜检查证据。术后,29例患者(71%)排尿正常,无明显残余尿量。8例患者(20%)仍需自行导尿,1例有持续性压力性尿失禁。当评估个体变量以确定其对尿道松解术预后的预测价值时,只有术前排尿后残余尿量具有统计学意义(排尿后残余尿量越大,失败的可能性越大,p = 0.021)。术前逼尿肌收缩的存在或强度以及压力 - 流率分析均不能预测预后。在压力性尿失禁患者中,15例(79%)治愈,3例(16%)明显改善,罕见的压力性尿失禁无需防护。总体而言,33例患者(80%)从手术中获益。在抗尿失禁手术导致梗阻或排空受损之前排尿正常的患者,不应仅基于低逼尿肌压力或压力 - 流率分析而被排除在尿道松解术之外。同时进行影像学成像和内镜检查可能有助于选择某些梗阻患者。