Satoh K, Narita M, Someya T, Fukuyama H, Yonekura Y
Department of Psychiatry, Shiga. University of Medical Sciences, Otsu, Japan.
Jpn J Psychiatry Neurol. 1993 Dec;47(4):881-5. doi: 10.1111/j.1440-1819.1993.tb01836.x.
A brain imaging study was conducted in the case of a catatonic type of schizophrenia (DSM-IIIR) by applying (i) positron emission tomography (PET) and (ii) single photon emission computed tomography (SPECT). A PET study using [18F]-2-fluoro-2-deoxy-D-glucose revealed a lower glucose utilization in the dorsal frontal and parietal lobes of both cerebral hemispheres. Correlative SPECT studies using [123I]-iodoamphetamine showed a diminished regional cerebral blood flow in similar regions of the cerebral hemisphere. A three-dimensional volume rendering method of the SPECT images (TITAN) identified the dorsal region of the fronto-parietal lobe as the most severely affected region. These patterns of deficits implicated the role of the dorsal frontal and parietal lobes in the pathogenesis of catatonic syndromes.
针对一名紧张型精神分裂症（DSM-IIIR）患者进行了一项脑成像研究，采用了（i）正电子发射断层扫描（PET）和（ii）单光子发射计算机断层扫描（SPECT）。一项使用[18F]-2-氟-2-脱氧-D-葡萄糖的PET研究显示，两个大脑半球的背侧额叶和顶叶葡萄糖利用率较低。使用[123I]-碘安非他明的相关SPECT研究表明，大脑半球类似区域的局部脑血流量减少。SPECT图像的三维容积再现方法（TITAN）确定额顶叶的背侧区域为受影响最严重的区域。这些缺陷模式表明背侧额叶和顶叶在紧张症综合征发病机制中的作用。
