颅内自我刺激和运动痕迹作为评估泛酸的指标。

Intracranial self-stimulation and locomotor traces as indicators for evaluating the homopantothenic acid.

作者信息

Takigawa M, Ueyama K, Fukuzako H, Maeda H, Matsumoto K

机构信息

Health Service Center, Kagoshima University, Japan.

出版信息

Jpn J Psychiatry Neurol. 1993 Dec;47(4):915-20. doi: 10.1111/j.1440-1819.1993.tb01841.x.

DOI:10.1111/j.1440-1819.1993.tb01841.x

PMID:8201803

Abstract

Our paper compares the effect of homopantothenic acid (HOPA) and haloperidol (HAL), i.e., representative neuroleptics, on intracranial self-stimulation (ICSS) and locomotor activity. These experiments showed that HOPA inhibited abnormal hyperactivity induced by methamphetamine (MAP) but did not inhibit ICSS which is considered with respect to physiological motivations. On the other hand, haloperidol (HAL) markedly inhibited both ICSS and abnormal hyperactivity induced by MAP. We propose that combined ICSS and locomotor traces can be chosen as indicators for evaluation and developing the new neuroleptics.

摘要

我们的论文比较了同型泛酸（HOPA）和氟哌啶醇（HAL）这两种代表性抗精神病药物对颅内自我刺激（ICSS）和运动活动的影响。这些实验表明，HOPA抑制了甲基苯丙胺（MAP）诱导的异常多动，但不抑制与生理动机相关的ICSS。另一方面，氟哌啶醇（HAL）显著抑制了MAP诱导的ICSS和异常多动。我们建议，可选择联合的ICSS和运动轨迹作为评估和开发新型抗精神病药物的指标。