脓毒症中细胞因子与白三烯B4的关系。
Relationship between cytokines and leukotriene B4 in sepsis.
作者信息
Nakae H, Endo S, Inada K, Takakuwa T, Kasai T, Yoshida M
机构信息
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1994 Feb;83(2):151-6.
To clarify the relationship between cytokines and arachidonic acid metabolites, we measured tumor necrosis factor (TNF-alpha), interleukin 8 (IL-8), and leukotriene B4 (LTB4). The subjects consisted of 30 patients with sepsis. The results were compared between patients who died (Group A) and those who survived (Group B). All TNF-alpha, IL-8, and LTB4 levels were significantly higher in Group A than in Group B, reflecting the severity of the disease. The LTB4 levels were significantly correlated with the TNF-alpha level and the IL-8 level. These results suggest that inflammatory cytokines, excessively produced due to inflammatory reactions, stimulate as a mediator the release of arachidonic acid, increasing LTB4 production.
为了阐明细胞因子与花生四烯酸代谢产物之间的关系，我们检测了肿瘤坏死因子（TNF-α）、白细胞介素8（IL-8）和白三烯B4（LTB4）。研究对象为30例脓毒症患者。对死亡患者（A组）和存活患者（B组）的结果进行了比较。A组中所有的TNF-α、IL-8和LTB4水平均显著高于B组，这反映了疾病的严重程度。LTB4水平与TNF-α水平和IL-8水平显著相关。这些结果表明，炎症反应过度产生的炎性细胞因子作为介质刺激花生四烯酸的释放，从而增加LTB4的产生。
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