Kasai T, Inada K, Takakuwa T, Yamada Y, Inoue Y, Shimamura T, Taniguchi S, Sato S, Wakabayashi G, Endo S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Res Commun Mol Pathol Pharmacol. 1997 Oct;98(1):34-42.
We measured the plasma levels of anti-inflammatory cytokines, including interleukin 1 receptor antagonist (IL-1ra), IL-4 and IL-10; inflammatory cytokines, including IL-2, IL-6, IL-8 and tumor necrosis factor receptor I and II (TNFR I and TNFR II); and endotoxin in 11 patients with septic shock associated with gram-negative bacteria and 12 patients with sepsis not associated with shock. The plasma levels of IL-1ra and IL-10 were elevated in the septic shock group compared with the sepsis group. TNFR I and TNFR II levels tend to be higher in the septic shock group. The plasma level of TRNF-alpha was significantly correlated with levels of IL-1ra, IL-4, IL-10, TNFR I, and TNFR II. The elevated levels of the anti-inflammatory cytokines, TNFR I, and TNFR II, appeared to reflect an attempt to suppress the shock syndrome.
我们检测了11例革兰氏阴性菌所致感染性休克患者及12例非休克性脓毒症患者血浆中抗炎细胞因子水平，包括白细胞介素1受体拮抗剂（IL-1ra）、IL-4和IL-10；炎性细胞因子水平，包括IL-2、IL-6、IL-8以及肿瘤坏死因子受体I和II（TNFR I和TNFR II）；以及内毒素水平。与脓毒症组相比，感染性休克组血浆IL-1ra和IL-10水平升高。感染性休克组TNFR I和TNFR II水平往往更高。TRNF-α的血浆水平与IL-1ra、IL-4、IL-10、TNFR I和TNFR II水平显著相关。抗炎细胞因子、TNFR I和TNFR II水平升高似乎反映了机体试图抑制休克综合征。
