Soravia C, Spiliopoulos A
Clinique de chirurgie thoracique, Hôpital cantonal universitaire, Genève.
Schweiz Med Wochenschr. 1994 Apr 30;124(17):725-8.
We report the case of a 36-year-old female with Fanconi's anemia who developed a squamous cell carcinoma of the esophagus which was treated by surgery. In the long term, Fanconi's anemia is associated with a high incidence of acute leukemia, liver tumors or squamous cell carcinomas of various organs. The high chromosome breakage of this disease is assumed to be a predisposing factor for malignant development. This elevated tumor incidence must be appreciated if early diagnosis and appropriate therapy are to be initiated.
我们报告了一例36岁患有范可尼贫血的女性病例，该患者患食管鳞状细胞癌并接受了手术治疗。从长远来看，范可尼贫血与急性白血病、肝肿瘤或各器官鳞状细胞癌的高发病率相关。这种疾病的高染色体断裂被认为是恶性肿瘤发生的一个易感因素。如果要启动早期诊断和适当治疗，就必须认识到这种升高的肿瘤发病率。
