[Dissociative phases and pathogenicity of different species of the Bacillus genus].

The previously postulated hypothesis, according to which different species of the genus Bacillus show strictly similar morphological and biological properties when the same variants are considered, has been confirmed by the present research. The "S" (smooth) variants of the five studied species (B. anthracis, B. subtilis, B. cereus, B. megaterium, B. mesentericus) are all lethal, at the experimented dose, for mice, whereas the "R" (rough, "star-shaped" colonies) variant of the same strains of the same species are all not pathogenic for the same animals. Likewise the "S" variants of three species tested in guinea pigs showed to be pathogenic; particularly B. anthracis and B. subtilis were lethal, whereas B. cereus caused a black eschar like that one described in the cutaneous anthrax. The "RS" variant ("medusae head" surface colonies) is not pathogenic for mice and guinea pigs (even B. anthracis) if the tested strains are cultivated for years in ordinary solid nutrient media; the same morphological variants are strongly pathogenic (also B. subtilis), when the strains are recently isolated from infected animals. The similarity between the same "S" variants of different species is proved also by the protection given by anti-anthrax serum to animals infected by B. subtilis.