静脉注射用脂肪乳剂：10%英脱利匹特临床应用经验
Fat emulsion for intravenous administration: clinical experience with intralipid 10%.
作者信息
Hansen L M, Hardie B S, Hidalgo J
出版信息
Ann Surg. 1976 Jul;184(1):80-8. doi: 10.1097/00000658-197607000-00014.
Abstract
A 10% soybean oil emulsion (Intralipid 10%), used extensively in Europe for intravenous alimentation, has now been clinically evaluated in the United States. Controlled studies have shown that the soybean oil emulsion can be substituted for glucose to supply one-third to two-thirds of the total calories, and can be administered peripherally without significant vein irritation. Essential fatty acid deficiencies, frequently encountered in patients dependent on parenteral alimentation with fat-free solutions, are prevented and corrected by use of this preparation. Data on long-term tolerance to Intralipid 10% infusions are presented for 292 patients treated for more than 6,000 patient days. The soybean oil emulsion was usually well tolerated. Side effects were reported in two of 133 adults and 12 of 159 pediatric patients.
摘要
一种10%的大豆油乳剂（英脱利匹特10%）在欧洲广泛用于静脉营养，目前已在美国进行了临床评估。对照研究表明，大豆油乳剂可替代葡萄糖提供总热量的三分之一至三分之二，并且可以外周给药而不会引起明显的静脉刺激。使用这种制剂可预防和纠正依赖无脂溶液进行胃肠外营养的患者中经常出现的必需脂肪酸缺乏症。本文给出了292例接受治疗超过6000个患者日的患者对10%英脱利匹特输注的长期耐受性数据。大豆油乳剂通常耐受性良好。133名成人中有2名、159名儿科患者中有12名报告了副作用。
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