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渗透应激下的血眼屏障。冻干眼研究。

The blood-ocular barriers under osmotic stress. Studies on the freeze-dried eye.

作者信息

Laties A M, Rapoport S

出版信息

Arch Ophthalmol. 1976 Jul;94(7):1086-91. doi: 10.1001/archopht.1976.03910040006002.

DOI:10.1001/archopht.1976.03910040006002
PMID:820318
Abstract

Regional differences in the response of primate blood-ocular barriers to severe osmotic stress were measured. Marker dyes were localized by fluorescence microscopy in tissues that had been freeze-dried to prevent diffusion. Under severe osmotic stress, the form and the function of the ciliary process are grossly compromised while the iris is spared. Breakdown of the retinal pigment epithelial barrier is widespread, while the retinal blood vessels in large areas retain normal permeability characteristics. The pigment epithelial barrier mechanism is substantially more susceptible to osmotic stress in the region surrounding the optic disc than in the equatorial area.

摘要

测量了灵长类动物血眼屏障对严重渗透压应激反应的区域差异。通过荧光显微镜对已冻干以防止扩散的组织中的标记染料进行定位。在严重渗透压应激下,睫状体的形态和功能受到严重损害,而虹膜则未受影响。视网膜色素上皮屏障的破坏很普遍,而大面积的视网膜血管保持正常的通透性特征。与赤道区域相比,视盘周围区域的色素上皮屏障机制对渗透压应激更敏感。

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The blood-ocular barriers under osmotic stress. Studies on the freeze-dried eye.渗透应激下的血眼屏障。冻干眼研究。
Arch Ophthalmol. 1976 Jul;94(7):1086-91. doi: 10.1001/archopht.1976.03910040006002.
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The structural basis of the blood-ocular barriers.血眼屏障的结构基础。
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Osmotic opening of blood-brain and blood-ocular barriers.血脑屏障和血眼屏障的渗透性开放。
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New developments in sustained release drug delivery for the treatment of intraocular disease.用于治疗眼内疾病的缓释药物递送的新进展。
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Response of choroidal vascular resistance to hyperglycemia.脉络膜血管阻力对高血糖的反应。
Int Ophthalmol. 1983 Feb;6(2):119-24. doi: 10.1007/BF00127640.
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Blood-retinal barrier permeability to carboxyfluorescein and fluorescein in monkeys.猴子中血视网膜屏障对羧基荧光素和荧光素的通透性
Graefes Arch Clin Exp Ophthalmol. 1986;224(5):419-22. doi: 10.1007/BF02173356.
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