Stancheva S, Papazova M, Alova L, Lazarova-Bakarova M
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
Acta Physiol Pharmacol Bulg. 1993;19(3):77-82.
The effect of neonatal 6-hydroxydopamine (6-OHDA) treatment on learning and retention and on the level of biogenic monoamines in some brain structures as well as the influence of the nootropic drugs--piracetam, aniracetam, meclofenoxate and fipexide on the 6-OHDA-induced effect was studied. Two- way active avoidance (shuttle box) was used. The levels of noradrenaline (NA), dopamine (DA) and serotonin (5-HT) in the frontal cortex, striatum, hypothalamus, hippocampus and pons were measured. In mature rats, injected with 6-OHDA (100 mg/kg s.c.) in the first 3 postnatal days learning and retention were impaired and the NA level in the frontal cortex and hippocampus was decreased. Piracetam (600 mg/kg), aniracetam (50 mg/kg), meclofenoxate (100 mg/kg) and fipexide (10 mg/kg) administered orally 5 days before and 5 days during training, abolished the amnestic effect of 6-OHDA and restored to control values the NA level in the frontal cortex and hippocampus. This finding suggests the important role of the noradrenergic neurotransmitter system in the 6-OHDA-induced amnesia, as well as in the favorable effect of the nootropic drugs tested on 6-OHDA-impaired memory processes.
研究了新生大鼠经6-羟基多巴胺（6-OHDA）处理对学习、记忆以及某些脑区生物源性单胺水平的影响，同时研究了促智药——吡拉西坦、阿尼西坦、甲氯芬酯和非哌西特对6-OHDA诱导效应的影响。采用双向主动回避（穿梭箱）实验。测定额叶皮质、纹状体、下丘脑、海马和脑桥中去甲肾上腺素（NA）、多巴胺（DA）和5-羟色胺（5-HT）的水平。在出生后前3天给成熟大鼠皮下注射6-OHDA（100mg/kg），可损害其学习和记忆能力，并降低额叶皮质和海马中的NA水平。在训练前5天和训练期间5天口服给予吡拉西坦（600mg/kg）、阿尼西坦（50mg/kg）、甲氯芬酯（100mg/kg）和非哌西特（10mg/kg），可消除6-OHDA的遗忘效应，并使额叶皮质和海马中的NA水平恢复至对照值。这一发现表明去甲肾上腺素能神经递质系统在6-OHDA诱导的失忆中起重要作用，同时也在受试促智药对6-OHDA损害的记忆过程的有益作用中起重要作用。
