Bergener M, Escher H D, Linden K J
Arzneimittelforschung. 1976 Feb;26(2):290-9.
In view of the particular problems of psychiatric classification the advantages and disadvantages of standardised rating scales are discussed. The result is that these instruments at present are irreplaceable in psychopathological research on behalf of their reliability in transmitting information and the possibility of quantifying psychopathological syndromes. The practice of 4 rating scales, which are still uncustomary mainly in the area of German language, is demonstrated by means of a psychopharmacological investigation example. These rating scales are: 1. the Hamilton Psychiatric Rating Scale for Depression, 2. the Wittenborn Psychiatric Rating Scale, 3. the Structured clinical Interview (Burdock and Hardesty) and 4. the Befindlichkeitsskala (Condition Scale) (v. Zerssen). Within a duration of treatment of 3 and 4 weeks desmethyl-loxapine [CL 67 772, 2-chloro-11-(1-piperazinyl)-dibenz (b,f)(1,4)-oxazepine] was tested in an open study as an antidepressant on 16 patients with different depressive syndromes. The results of treatment, which can be considered positive, are represented and discussed in an intra-individual pre- and after-treatment comparison in respect of the differences between these scales. The good therapeutic efficacy of desmethyl-loxapine results mainly from a marked anxiolytic effect. All the clinical and chemical examinations performed point out an excellent tolerance of this drug. German versions of standardised rating scales appear urgently indicated.
鉴于精神科分类的特殊问题，本文讨论了标准化评定量表的优缺点。结果表明，目前这些工具在精神病理学研究中是不可替代的，因为它们在传递信息方面具有可靠性，并且能够对精神病理综合征进行量化。通过一个精神药理学研究实例展示了4种评定量表的应用情况，这4种量表在德语区主要仍不常用。这些评定量表分别是：1. 汉密尔顿抑郁量表；2. 维滕伯恩精神评定量表；3. 结构化临床访谈（伯多克和哈迪斯蒂）；4. 状态量表（策尔森）。在一项开放性研究中，对16例患有不同抑郁综合征的患者使用去甲氯氮平[CL 67 772，2-氯-11-（1-哌嗪基）-二苯并（b,f）（1,4）-恶嗪]作为抗抑郁药进行了为期3至4周的治疗测试。在个体内治疗前和治疗后比较中，根据这些量表之间的差异呈现并讨论了可视为阳性的治疗结果。去甲氯氮平良好的治疗效果主要源于其显著的抗焦虑作用。所有进行的临床和化学检查均表明该药物耐受性良好。标准化评定量表的德语版本显得十分必要。
