Kawabe H, Saito I, Hasegawa C, Nagano S, Saruta T
Health Center, Keio University, Tokyo, Japan.
Angiology. 1994 Jun;45(6):435-41. doi: 10.1177/000331979404500604.
To determine whether any differences exist between young male subjects with elevated diastolic and systolic blood pressure (BP) and those with only an elevated systolic BP, the responses of BP and plasma catecholamines to a mental arithmetic test were studied in 11 young men (mean age of nineteen years) with BP of > or = 140/90 mm Hg at a routine health check-up (group I-hypertension [HT]), 26 age-matched men with only elevated systolic BP (> or = 140 mm Hg) (group II-HT), and 12 age-matched normotensive (NT) men (< 140/90 mm Hg). During an arithmetic test, group I-HT showed a significantly higher increment of systolic BP (+14.5-18.0%) than group II-HT (+9.3-10.2%) and NT controls (+6.4-8.2%). However, no significant difference in BP response was seen between group II-HT and NT controls. Plasma norepinephrine in group I-HT showed a significant increase after the test, (171 +/- 23-->202 +/- 27 pg/mL), whereas group II-HT and NT controls showed no change. No significant difference occurred in epinephrine response among the three groups. These results suggest that the young male subjects with screening BP above 140/90 mm Hg are hyperreactive to a mental stress as compared with subjects with only elevated systolic BP or NT controls.
为了确定舒张压和收缩压升高的年轻男性受试者与仅收缩压升高的男性受试者之间是否存在差异，我们对11名在常规健康检查时血压≥140/90 mmHg的年轻男性（平均年龄19岁）（I组 - 高血压[HT]）、26名年龄匹配且仅收缩压升高（≥140 mmHg）的男性（II组 - HT）和12名年龄匹配的血压正常（NT）男性（<140/90 mmHg）进行了研究，观察他们的血压和血浆儿茶酚胺对心算测试的反应。在心算测试期间，I组 - HT的收缩压升高幅度（+14.5 - 18.0%）显著高于II组 - HT（+9.3 - 10.2%）和NT对照组（+6.4 - 8.2%）。然而，II组 - HT和NT对照组之间在血压反应上没有显著差异。I组 - HT的血浆去甲肾上腺素在测试后显著增加（171±23 --> 202±27 pg/mL），而II组 - HT和NT对照组没有变化。三组之间肾上腺素反应没有显著差异。这些结果表明，与仅收缩压升高的受试者或血压正常对照组相比，筛查血压高于140/90 mmHg的年轻男性受试者对精神压力反应过度。
