Nawwar G A
National Research Centre, Dokki, Cairo, Egypt.
Arch Pharm (Weinheim). 1994 Apr;327(4):201-5. doi: 10.1002/ardp.19943270402.
Salicylamide amino acid conjugates were prepared utilizing 5-formyl-, 5-dicyanoethenyl-, and 5-nitroethenylsalicylic acid. 5-Substituted salicylanilides were treated with glycine and formaldehyde in a Mannich type reaction affording the corresponding 3-(N-glycino)salicylanilides. The reactions of anilines with pyrans containing the salicylyl moiety yielded the corresponding salicylanilides. The obtained compounds were tested for molluscicidal activity.
利用5-甲酰基水杨酸、5-二氰基乙烯基水杨酸和5-硝基乙烯基水杨酸制备了水杨酰胺氨基酸共轭物。5-取代水杨酰苯胺在曼尼希型反应中与甘氨酸和甲醛反应，得到相应的3-(N-甘氨酸)水杨酰苯胺。苯胺与含有水杨酰基部分的吡喃反应生成相应的水杨酰苯胺。对所得到的化合物进行了杀螺活性测试。
