Reis R P, Azinheira J, Reis H P, Vilaverde M M, Bordalo e Sá A, Santos L, Adão M, Pina J E, Ferreira N C, Luís A S
Serviço de Cardiologia, Hospital Distrital do Barreiro.
Rev Port Cardiol. 1994 Feb;13(2):119-24, 103.
To investigate if hyper-homocysteinemia represents an independent risk factor of early coronary disease.
We studied a group of patients under 45 years old, that suffered a myocardial infarction from 3 months and 1 year before the study. The patients were matched with a group of normal controls of a check-up program, in terms of age, sex, smoking habits, presence of hypertension, obesity, (Quetelet Index), presence of diabetes, basal glycemia, total cholesterol, LDL and HDL cholesterol. Later we measured to patients (Pts) and controls (Cts) the plasmatic basal homocysteinemia (B HC) and 6 hours after a methionine overload of 0.1 g/kg body weight (L HC).
[table: see text]
In this study hyper-homocysteinemia appears as an independent risk factor of early coronary disease. The measurement of homocysteinemia after the methionine loading test was more discriminative than the basal measurement.
研究高同型半胱氨酸血症是否为早期冠心病的独立危险因素。
我们研究了一组45岁以下的患者，这些患者在研究前3个月至1年发生过心肌梗死。将这些患者与一组体检项目中的正常对照者在年龄、性别、吸烟习惯、高血压、肥胖（体重指数）、糖尿病、基础血糖、总胆固醇、低密度脂蛋白和高密度脂蛋白胆固醇方面进行匹配。随后，我们测量了患者（Pts）和对照者（Cts）的血浆基础同型半胱氨酸血症（B HC）以及在0.1 g/kg体重蛋氨酸负荷后6小时的同型半胱氨酸血症（L HC）。
[表格：见正文]
在本研究中，高同型半胱氨酸血症表现为早期冠心病的独立危险因素。蛋氨酸负荷试验后同型半胱氨酸血症的测量比基础测量更具鉴别力。
