Arbab A S, Koizumi K, Uchiyama G, Arai T, Eguchi H, Matsumoto Y, Suda K
Department of Radiology, Yamanashi Medical University, Japan.
Ann Nucl Med. 1994 Feb;8(1):9-15. doi: 10.1007/BF03164981.
A total of 7 (4 males and 3 females) patients were included in this retrospective study to determine the sensitivity of radioimmunoscintigraphy with I-131 labeled anti CEA/CA 19-9 monoclonal antibodies. Out of 7 patients 2 had ascending colon cancer, one had sigmoid colon cancer, one had rectal cancer and one had adenocarcinoma in the CBD and the remaining two had metastatic tumor (one in the lungs and the other in the liver). Whole body as well as spot images showed a 72% (5/7) positive scan. But post operative specimen counts and imaging showed a high tumor to non-tumor ratio and a good tumor to non-tumor contrast of activity of I-131 labeled monoclonal antibody. We did not find any relation between CEA/CA 19-9 levels and scan findings. A case of liver metastasis was also detected by this radioimmunoscintigraphy.
本回顾性研究共纳入7例患者（4例男性，3例女性），以确定用I-131标记的抗CEA/CA 19-9单克隆抗体进行放射免疫闪烁显像的敏感性。7例患者中，2例为升结肠癌，1例为乙状结肠癌，1例为直肠癌，1例为胆总管腺癌，其余2例为转移瘤（1例在肺，另1例在肝）。全身及局部图像显示扫描阳性率为72%（5/7）。但术后标本计数及显像显示，I-131标记单克隆抗体的肿瘤与非肿瘤比值高，肿瘤与非肿瘤的活性对比良好。我们未发现CEA/CA 19-9水平与扫描结果之间存在任何关联。通过这种放射免疫闪烁显像还检测出1例肝转移病例。
