Costentin J, Marçais H, Protais P, Schwartz J C
C R Acad Hebd Seances Acad Sci D. 1976 Mar 1;282(9):913-6.
The climbing behaviour, a stereotyped motor behaviour, is elicited in mice by stimulation of striatal dopamine receptor by low doses of apomorphine. The action of apomorphine is unexpectedly enhanced in animals pretreated with a single dose of this agent (5 mg/kg). This enhancement occurs as early as 2 h following the first administration and persists for at least 3 days. It is also observed after pretreatments with a combination of L-DOPA and dexamphetamine. This effect seems independent from the desensitization of the dopaminergic receptors involved in thermoregulation that we have previously reported.
攀爬行为是一种刻板的运动行为，低剂量阿扑吗啡刺激纹状体多巴胺受体可在小鼠中引发该行为。在单次给予该药物（5毫克/千克）预处理的动物中，阿扑吗啡的作用意外增强。这种增强最早在首次给药后2小时出现，并持续至少3天。在用左旋多巴和右旋苯丙胺联合预处理后也观察到这种效应。这种作用似乎与我们之前报道的参与体温调节的多巴胺能受体脱敏无关。
