Verjee Z H, Behal R
Clin Chim Acta. 1976 Jul 1;70(1):139-47. doi: 10.1016/0009-8981(76)90016-4.
This paper reports a study of changes in red blood cell enzymes and some serum parameters during and after treatment of protein-calorie malnutrition. The red cell GSH levels were low during the crisis, together with the levels of GSSG:NADPH reductase, GSH:H2O2 peroxidase, aspartate aminotransferase and alanine aminotransferase. After treatment the levels of all these enzymes increased significantly to normal values. Of the serum parameters investigated, significant reduction in the activity of the enzymes cholinesterase, catecholamine oxidase, total proteins, albumin, urea and electrolytes were obvious, and returned to normal values after treatment. Ceruloplasmin activity remained low even after three weeks' treatment and could not be related to copper levels. The results are discussed in relation to anemia and liver damage that may accompany the syndrome.
本文报道了一项关于蛋白质-热量营养不良治疗期间及治疗后红细胞酶和一些血清参数变化的研究。在病情危急期，红细胞谷胱甘肽（GSH）水平较低，同时谷胱甘肽二硫化物：烟酰胺腺嘌呤二核苷酸磷酸（GSSG:NADPH）还原酶、谷胱甘肽：过氧化氢（GSH:H2O2）过氧化物酶、天冬氨酸转氨酶和丙氨酸转氨酶的水平也较低。治疗后，所有这些酶的水平均显著升高至正常值。在所研究的血清参数中，胆碱酯酶、儿茶酚胺氧化酶、总蛋白、白蛋白、尿素和电解质的酶活性明显降低，治疗后恢复至正常值。即使经过三周治疗，铜蓝蛋白活性仍较低，且与铜水平无关。结合可能伴随该综合征出现的贫血和肝损伤对结果进行了讨论。
