Anders R F, Price M A, Wilkey I S, Husby G, Takitaki F, Natvig J B, McAdam K P
Clin Exp Immunol. 1976 Apr;24(1):49-53.
In this study of protein composition of amyloid fibrils isolated from eight patients representative of the spectrum of amyloidosis found in Papua New Guinea has been investigated. All fibril preparations, including three from patients with amyloidosis secondary to lepromatous leprosy and one from an unusual juvenile case of primary amyloidosis, contained the non-immunogobulin amyloid protein, protein AA. However, only 44% of thirty-six amyloid patients had detectable levels of the protein AA-related serum component, protein SAA. Alkali-degraded material from each of the fibril preparations failed to react in double immunodiffusion test with antiserum to the amyloid-related light chain VgammaV, but evidence was found for this immunoglobulin light chain-specificity in the serum of one patient.
在这项研究中，对从巴布亚新几内亚发现的淀粉样变性谱系中选取的8名患者所分离出的淀粉样纤维的蛋白质组成进行了调查。所有纤维制剂，包括3例继发于瘤型麻风的淀粉样变性患者的制剂以及1例原发性淀粉样变性的罕见青少年病例的制剂，均含有非免疫球蛋白淀粉样蛋白AA。然而，36例淀粉样变性患者中只有44%的患者血清中可检测到与蛋白质AA相关的成分，即蛋白质SAA。各纤维制剂经碱降解后的物质在双向免疫扩散试验中不能与抗淀粉样相关轻链VγV抗血清发生反应，但在1例患者的血清中发现了这种免疫球蛋白轻链特异性的证据。
