Husby G, Sletten K, Blumenkrantz N, Danielsen L
Clin Exp Immunol. 1981 Jul;45(1):90-6.
Amyloid fibrils obtained from a case (Hud) of localized, tumorous amyloidosis of the skin were investigated by immunological and biochemical methods including amino acid sequence studies. Evidence was obtained that a lambda immunoglobulin light chain protein, A lambda I, and differently sized N terminal fragments (mol. wt 14,000 and 10,000) of the same protein comprised a major component of the fibrils. The chemical nature of this protein suggested that this case of cutaneous amyloidosis belonged to the idiopathic form of amyloidosis, probably as a special type of systemic, idiopathic amyloid disease.
通过包括氨基酸序列研究在内的免疫学和生化方法，对取自一例局限性皮肤肿瘤性淀粉样变性病例（Hud）的淀粉样纤维进行了研究。有证据表明，一种λ免疫球蛋白轻链蛋白AλI以及该蛋白不同大小的N端片段（分子量分别为14,000和10,000）构成了纤维的主要成分。这种蛋白的化学性质表明，该皮肤淀粉样变性病例属于淀粉样变性的特发性形式，可能是系统性特发性淀粉样疾病的一种特殊类型。
