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[芬乙茶碱对创伤性水肿和肿胀时脑线粒体超微结构的影响]

[The effect of fenibut on the ultrastructure of the brain mitochondria in traumatic edema and swelling].

作者信息

Novikov V E, Naperstnikov V V

出版信息

Eksp Klin Farmakol. 1994 Mar-Apr;57(2):13-6.

PMID:8205040
Abstract

Rat experiments using electron microscopy have established that profound destructive changes occur in the mitochondria in the intra- and perifocal traumatic area in dynamics of traumatic edema-swelling. With phenibut, 50 mg/kg, there is an increase in the number of mitochondria in the brain tissue of the perifocal area, their destructive changes are less pronounced. It is assumed that the positive effect of phenibut on brain bioenergetic processes in the posttraumatic period is associated with the changes.

摘要

利用电子显微镜进行的大鼠实验已证实,在创伤性水肿-肿胀动态过程中,病灶内和病灶周围创伤区域的线粒体发生了严重的破坏性变化。给予50mg/kg的苯乙哌啶酮后,病灶周围区域脑组织中的线粒体数量增加,其破坏性变化不那么明显。据推测,苯乙哌啶酮在创伤后时期对脑生物能过程的积极作用与这些变化有关。

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